Which of these statements about how Sinus Arrhythmia differs from wandering?

A premature atrial contraction occurs when a focus in the atrium (not the sinoatrial node) generates an action potential before the next scheduled SA node action potential.

There are four main characteristics of PACs:

  1. Premature, occurring earlier than expected if measured against previous P-P intervals.
  2. Ectopic, originating outside of the SA node, and thus, the P wave morphology would be different from the normal sinus P wave morphology.
  3. Narrow complexes; because they come from the atrium, they will eventually travel through the AV node and use the normal conduction system to spread to the ventricles. Unlike premature ventricular contractions, or PVCs, which are wide-complexed because they do not use the normal ventricular conduction system. Less commonly, PACs can conduct aberrantly in a right or left bundle pattern, which can make it challenging to differentiate them from PVCs.
  4. Compensatory pause following the contraction; the extra atrial action potential causes the SA node to become refractory to generating its next scheduled beat, and thus it must “skip a beat” and will resume exactly 2 P-P intervals after the last normal sinus beat.

When every other QRS complex is a premature atrial contraction, then the rhythm is referred to as “atrial bigeminy” as seen in this strip above.

If a PAC occurs when the AV node has not yet recovered from the refractory period, it will fail to conduct to the ventricles; this means there will not be a QRS complex following, or the ectopic PR interval will be prolonged. The ECG will show a premature, ectopic P wave and then no QRS complex afterward. When this occurs in a pattern of bigeminy, the interpreter may be fooled into thinking that sinus bradycardia is present, because every other beat is a nonconducted PAC, and the QRS rate is quite slow.

Ashman’s Phenomenon, also known as the Ashman Beat, occurs when a PAC or supraventricular beat occurs before the right bundle branch has recovered from its refractory period. This results in the premature beat displaying a right bundle branch block pattern and can be confused with a premature ventricular contraction.

Although rarely fatal, disorders of sinus node function and atrial arrhythmias are causes of much morbidity. They are the most common causes of clinical bradyarrhythmias and tachyarrhythmias, respectively. Sinus node dysfunction accounts for over half of permanent pacemaker implants worldwide [1], while atrial fibrillation occurs secondary to the progression of most cardiac conditions [2]. The sinus node and the atrium are closely related, both anatomically and functionally, and disorders of one interfere with the functioning of the other. This fact is of particular relevance to the electrocardiographic study of sinus and atrial activity.

The electrocardiographic diagnosis both of sinus disorders and atrial arrhythmias depends on the P wave as evidence of atrial activation, since sinus node activity itself is not recorded on the surface ECG. The presence or absence of P waves, their morphology and timing, including their relation to ventricular activation as...

Keywords

  • Atrial Flutter
  • Sinus Node
  • Atrial Tachycardia
  • Atrial Arrhythmia
  • Sick Sinus Syndrome

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Figure 26.1

Which of these statements about how Sinus Arrhythmia differs from wandering?

Figure 26.2

Which of these statements about how Sinus Arrhythmia differs from wandering?

Figure 26.3

Which of these statements about how Sinus Arrhythmia differs from wandering?

Figure 26.4

Which of these statements about how Sinus Arrhythmia differs from wandering?

Figure 26.5

Which of these statements about how Sinus Arrhythmia differs from wandering?

Figure 26.6

Which of these statements about how Sinus Arrhythmia differs from wandering?

Figure 26.7

Which of these statements about how Sinus Arrhythmia differs from wandering?

Figure 26.8

Which of these statements about how Sinus Arrhythmia differs from wandering?

Figure 26.9

Which of these statements about how Sinus Arrhythmia differs from wandering?

Figure 26.10

Which of these statements about how Sinus Arrhythmia differs from wandering?

Figure 26.11

Which of these statements about how Sinus Arrhythmia differs from wandering?

Figure 26.12

Which of these statements about how Sinus Arrhythmia differs from wandering?

Figure 26.13

Which of these statements about how Sinus Arrhythmia differs from wandering?

Figure 26.14

Which of these statements about how Sinus Arrhythmia differs from wandering?

Figure 26.15

Which of these statements about how Sinus Arrhythmia differs from wandering?

Figure 26.16

Which of these statements about how Sinus Arrhythmia differs from wandering?

Figure 26.17

Which of these statements about how Sinus Arrhythmia differs from wandering?

Figure 26.18

Which of these statements about how Sinus Arrhythmia differs from wandering?

Figure 26.19

Which of these statements about how Sinus Arrhythmia differs from wandering?

Figure 26.20

Which of these statements about how Sinus Arrhythmia differs from wandering?

References

  1. Kusumoto, F.M., and N. Goldschlager, Cardiac pacing. N. Engl. J. Med., 1996;334: 89–97.

    CrossRef  PubMed  CAS  Google Scholar 

  2. Kannel, W.B., P.A. Wolf, E.J. Benjamin, and D. Levy, Prevalence, incidence, prognosis, and predisposing conditions for atrial fibrillation: population-based estimates. Am. J. Cardiol., 1998;82: 2N–9N.

    CrossRef  PubMed  CAS  Google Scholar 

  3. Mandel, W., H. Hayakawa, R. Danzig, and H.S. Marcus, Evaluation of sino-atrial node function in man by overdrive suppression. Circulation, 1971;44: 59–66.

    CrossRef  PubMed  CAS  Google Scholar 

  4. Reiffel, J.A. and M.J. Kuehnert, Electrophysiological testing of sinus node function: diagnostic and prognostic application-including updated information from sinus node electrograms. Pace Clin. Electrophysiol., 1994;17: 349–365.

    CrossRef  CAS  Google Scholar 

  5. Callans, D.J., D. Schwartzman, C.D. Gottlieb, and F.E. Marchlinski, Insights into the electrophysiology of atrial arrhythmias gained by the catheter ablation experience: “learning while burning, Part II.” J. Cardiovasc. Electrophysiol., 1995;6: 229–243.

    CrossRef  PubMed  CAS  Google Scholar 

  6. Brignole, M., P. Alboni, D.G. Benditt, L. Bergfeldt, J.J. Blanc, P.E.B. Thomsen, et al., Guidelines on management (diagnosis and treatment) of syncope – update 2004. The task force on syncope, European Society of Cardiology. Europace, 2004;6: 467–547.

    CrossRef  PubMed  Google Scholar 

  7. Epstein, A.E., J.P. DiMarco, K.A. Ellenbogen, N.A.M. Estes III, R.A. Freedman, L.S. Gettes, et al, ACC/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines (Writing Committee to revise the ACC/AHA/NASPE 2002 guideline update for implantation of cardiac pacemakers and antiarrhythmia devices). J. Am. Coll. Cardiol., 2008;51: e1–e62.

    CrossRef  PubMed  Google Scholar 

  8. Benditt, D.G., C.C. Gornick, D. Dunbar, A. Almquist, and S. Pool-Schneider, Indications for electrophysiologic testing in the diagnosis and assessment of sinus node dysfunction. Circulation, 1987;75: III93–102.

    CrossRef  PubMed  CAS  Google Scholar 

  9. James, T.N., Structure and function of the sinus node, AV node and His bundle of the human heart: part I-structure. Prog. Cardiovasc. Dis., 2002;45: 235–267.

    CrossRef  PubMed  Google Scholar 

  10. Sanchez-Quintana, D., J.A. Cabrera, J. Farre, V. Climent, R.H. Anderson, and S.Y. Ho, Sinus node revisited in the era of electroanatomical mapping and catheter ablation. Heart, 2005;91: 189–194.

    CrossRef  PubMed  CAS  Google Scholar 

  11. Irisawa, H., T. Nakayama, and A. Noma, Membrane currents of single pacemaker cells from rabbit S-A and A-V nodes, in D. Noble and T. Powell, Editors. London: Academic Press, 1987, pp. 167–186.

    Google Scholar 

  12. Mitsuiye, T., Y. Shinagawa, and A. Noma, Sustained inward current during pacemaker depolarization in mammalian sinoatrial node cells. Circ. Res., 2000;87: 88–91.

    CrossRef  PubMed  CAS  Google Scholar 

  13. Mangoni, M.E., B. Couette, E. Bourinet, J. Platzer, D. Reimer, J. Striessnig, et al., Functional role of L-type Cav1.3 Ca2 + channels in cardiac pacemaker activity. Proc. Natl. Acad. Sci. U.S.A., 2003;100: 5543–5548.

    CrossRef  PubMed  CAS  Google Scholar 

  14. Stieber, J., F. Hofmann, and A. Ludwig, Pacemaker channels and sinus node arrhythmia. Trends Cardiovasc. Med., 2004;14: 23–28.

    CrossRef  PubMed  CAS  Google Scholar 

  15. Cho, H.S., M. Takano, and A. Noma, The electrophysiological properties of spontaneously beating pacemaker cells isolated from mouse sinoatrial node. J. Physiol. (Lond.), 2003;550: 169–180.

    CrossRef  CAS  Google Scholar 

  16. Vinogradova, T.M., V.A. Maltsev, K.Y. Bogdanov, A.E. Lyashkov, and E.G. Lakatta, Rhythmic Ca2 + oscillations drive sinoatrial nodal cell pacemaker function to make the heart tick. Ann. N.Y. Acad. Sci., 2005;1047: 138–156.

    CrossRef  PubMed  CAS  Google Scholar 

  17. Bleeker, W.K., A.J. Mackaay, M. Masson-Pevet, L.N. Bouman, and A.E. Becker, Functional and morphological organization of the rabbit sinus node. Circ. Res., 1980;46: 11–22.

    CrossRef  PubMed  CAS  Google Scholar 

  18. Morton, H.J. and E.T. Thomas, Effect of atropine on the heart-rate. Lancet, 1958;2: 1313–1315.

    CrossRef  PubMed  CAS  Google Scholar 

  19. WHO/ISFC Task Force, Definition of terms related to cardiac rhythm. Am. Heart J., 1978;95: 796–806.

    CrossRef  Google Scholar 

  20. Spodick, D.H., P. Raju, R.L. Bishop, and R.D. Rifkin, Operational definition of normal sinus heart rate. Am. J. Cardiol., 1992;69: 1245–1246.

    CrossRef  PubMed  CAS  Google Scholar 

  21. Brignole, M., Sick sinus syndrome. Clin. Geriatr. Med., 2002;18: 211–227.

    CrossRef  PubMed  Google Scholar 

  22. Scott, O., G.J. Williams, and G.I. Fiddler, Results of 24 hour ambulatory monitoring of electrocardiogram in 131 healthy boys aged 10 to 13 years. Br. Heart J., 1980;44: 304–308.

    CrossRef  PubMed  CAS  Google Scholar 

  23. Brodsky, M., D. Wu, P. Denes, C. Kanakis, and K.M. Rosen, Arrhythmias documented by 24 hour continuous electrocardiographic monitoring in 50 male medical students without apparent heart disease. Am. J. Cardiol., 1977;39: 390–395.

    CrossRef  PubMed  CAS  Google Scholar 

  24. Bjerregaard, P., Mean 24 hour heart rate, minimal heart rate and pauses in healthy subjects 40–79 years of age. Eur. Heart J., 1983;4: 44–51.

    PubMed  CAS  Google Scholar 

  25. Talan, D.A., R.A. Bauernfeind, W.W. Ashley, C. Kanakis Jr., and K.M. Rosen, Twenty-four hour continuous ECG recordings in long-distance runners. Chest, 1982;82: 19–24.

    CrossRef  PubMed  CAS  Google Scholar 

  26. Adgey, A.A., J.S. Geddes, H.C. Mulholland, D.A. Keegan, and J.F. Pantridge, Incidence, significance, and management of early bradyarrhythmia complicating acute myocardial infarction. Lancet, 1968;2: 1097–1101.

    CrossRef  PubMed  CAS  Google Scholar 

  27. Alpert, M.A. and G.C. Flaker, Arrhythmias associated with sinus node dysfunction. Pathogenesis, recognition, and management. JAMA, 1983;250: 2160–2166.

    CrossRef  PubMed  CAS  Google Scholar 

  28. Adan, V. and L.A. Crown, Diagnosis and treatment of sick sinus syndrome. Am. Fam. Physician, 2003;67: 1725–1732.

    PubMed  Google Scholar 

  29. Sheffield, L.T., J.H. Holt, and T.J. Reeves, Exercise graded by heart rate in electrocardiographic testing for angina pectoris. Circulation, 1965;32: 622–629.

    CrossRef  PubMed  CAS  Google Scholar 

  30. Tanaka, H., K.D. Monahan, and D.R. Seals, Age-predicted maximal heart rate revisited. J. Am. Coll. Cardiol., 2001;37: 153–156.

    CrossRef  PubMed  CAS  Google Scholar 

  31. Yasuma, F. and J. Hayano, Respiratory sinus arrhythmia: why does the heartbeat synchronize with respiratory rhythm? Chest, 2004;125: 683–690.

    CrossRef  PubMed  Google Scholar 

  32. Rosenbaum, M.B. and E. Lepeschin, The effect of ventricular systole on auricular rhythm in auriculoventricular block. Circulation, 1955;11: 240–261.

    CrossRef  PubMed  CAS  Google Scholar 

  33. de Marchena, E., M. Colvin-Adams, J. Esnard, M. Ridha, A. Castellanos, and R.J. Myerburg, Ventriculophasic sinus arrhythmia in the orthotopic transplanted heart: mechanism of disease revisited. Int. J. Cardiol., 2003;91: 71–74.

    CrossRef  PubMed  Google Scholar 

  34. Bauernfeind, R.A., F. Amat-y-Leon, R.C. Dhingra, R. Kehoe, C. Wyndham, and K.M. Rosen, Chronic nonparoxysmal sinus tachycardia in otherwise healthy persons. Ann. Intern. Med., 1979;91: 702–710.

    PubMed  CAS  Google Scholar 

  35. Brady, P.A., P.A. Low, and W.K. Shen, Inappropriate sinus tachycardia, postural orthostatic tachycardia syndrome, and overlapping syndromes. Pace Clin. Electrophysiol., 2005;28: 1112–1121.

    CrossRef  Google Scholar 

  36. Narula, O.S., Sinus node re-entry: a mechanism for supraventricular tachycardia. Circulation, 1974;50: 1114–1128.

    CrossRef  PubMed  CAS  Google Scholar 

  37. Sperry, R.E., K.A. Ellenbogen, M.A. Wood, M.K. Belz, and B.S. Stambler, Radiofrequency catheter ablation of sinus node reentrant tachycardia. Pace Clin. Electrophysiol., 1993;16: 2202–2209.

    CrossRef  CAS  Google Scholar 

  38. Gomes, J.A., D. Mehta, and M.N. Langan, Sinus node reentrant tachycardia. Pace Clin. Electrophysiol., 1995;18: 1045–1057.

    CrossRef  CAS  Google Scholar 

  39. Gomes, J.A., R.J. Hariman, P.S. Kang, and I.H. Chowdry, Sustained symptomatic sinus node reentrant tachycardia: incidence, clinical significance, electrophysiologic observations and the effects of antiarrhythmic agents. J. Am. Coll. Cardiol., 1985;5: 45–57.

    CrossRef  PubMed  CAS  Google Scholar 

  40. Damato, A.N., Clinical evidence for sinus node reentry, in The Sinus Node: Structure, Function and Clinical Relevance, F.I.M. Bonke, Editor. The Hague: Nijhoff, 1978, pp. 379–388.

    Google Scholar 

  41. Bashour, T.T., Classification of sinus node dysfunction. Am. Heart J., 1985;110: 1251–1256.

    CrossRef  PubMed  CAS  Google Scholar 

  42. Thery, C., B. Gosselin, J. Lekieffre, and H. Warembourg, Pathology of sinoatrial node. Correlations with electrocardiographic findings in 111 patients. Am. Heart J., 1977;93: 735–740.

    CrossRef  PubMed  CAS  Google Scholar 

  43. Evans, R. and D.B. Shaw, Pathological studies in sinoatrial disorder (sick sinus syndrome). Br. Heart J., 1977;39: 778–786.

    CrossRef  PubMed  CAS  Google Scholar 

  44. Bharati, S., A. Nordenberg, R. Bauernfiend, J.P. Varghese, A.G. Carvalho, K. Rosen, et al., The anatomic substrate for the sick sinus syndrome in adolescence. Am. J. Cardiol., 1980;46: 163–172.

    CrossRef  PubMed  CAS  Google Scholar 

  45. Rosen, K.M., H.S. Loeb, M.Z. Sinno, S.H. Rahimtoola, and R.M. Gunnar, Cardiac conduction in patients with symptomatic sinus node disease. Circulation, 1971;43: 836–844.

    CrossRef  PubMed  CAS  Google Scholar 

  46. Narula, O.S., Atrioventricular conduction defects in patients with sinus bradycardia. Analysis by His bundle recordings. Circulation, 1971;44: 1096–1110.

    CrossRef  PubMed  CAS  Google Scholar 

  47. Kaplan, B.M., R. Langendorf, M. Lev, and A. Pick, Tachycardia-bradycardia syndrome (so-called “sick sinus syndrome”). Pathology, mechanisms and treatment. Am. J. Cardiol., 1973;31: 497–508.

    CrossRef  PubMed  CAS  Google Scholar 

  48. Demoulin, J.C. and H.E. Kulbertus, Histopathological correlates of sinoatrial disease. Br. Heart J., 1978;40: 1384–1389.

    CrossRef  PubMed  CAS  Google Scholar 

  49. Hwang, Y.T., C.D. Tseng, J.J. Hwang, K.L. Hsu, F.T. Chiang, Y.Z. Tseng, et al., Cardiac amyloidosis presenting as sick sinus syndrome and intractable heart failure: report of a case. J. Formos. Med. Assoc., 1993;92: 283–287.

    PubMed  CAS  Google Scholar 

  50. Wang, T.L., W.J. Chen, C.S. Liau, and Y.T. Lee, Sick sinus syndrome as the early manifestation of cardiac hemochromatosis. J. Electrocardiol., 1994;27: 91–96.

    CrossRef  PubMed  CAS  Google Scholar 

  51. Watt, A.H., Sick sinus syndrome: an adenosine-mediated disease. Lancet, 1985;1: 786–788.

    CrossRef  PubMed  CAS  Google Scholar 

  52. Benedini, G., C. Cuccia, R. Bolognesi, A. Affatato, G. Gallo, E. Renaldini, et al., Value of purinic compounds in assessing sinus node dysfunction in man: a new diagnostic method. Eur. Heart J., 1984;5: 394–403.

    PubMed  CAS  Google Scholar 

  53. Benditt, D.G., D.W. Benson Jr., J. Kreitt, A. Dunnigan, M.R. Pritzker, L. Crouse, et al., Electrophysiologic effects of theophylline in young patients with recurrent symptomatic bradyarrhythmias. Am. J. Cardiol., 1983;52: 1223–1229.

    CrossRef  PubMed  CAS  Google Scholar 

  54. Alboni, P., C. Menozzi, M. Brignole, N. Paparella, G. Gaggioli, G. Lolli, et al., Effects of permanent pacemaker and oral theophylline in sick sinus syndrome the THEOPACE study: a randomized controlled trial. Circulation, 1997;96: 260–266.

    CrossRef  PubMed  CAS  Google Scholar 

  55. Maisch, B., U. Lotze, J. Schneider, and K. Kochsiek, Antibodies to human sinus node in sick sinus syndrome. Pace Clin. Electrophysiol., 1986;9: 1101–1109.

    CrossRef  CAS  Google Scholar 

  56. Lown, B., Electrical reversion of cardiac arrhythmias. Br. Heart J., 1967;29: 469–489.

    CrossRef  PubMed  CAS  Google Scholar 

  57. Ferrer, M.I., The sick sinus syndrome in atrial disease. JAMA, 1968;206: 645–646.

    CrossRef  PubMed  CAS  Google Scholar 

  58. Bigger, J.T. Jr. and J.A. Reiffel, Sick sinus syndrome. Annu. Rev. Med., 1979;30: 91–118.

    CrossRef  PubMed  Google Scholar 

  59. Rubenstein, J.J., C.L. Schulman, P.M. Yurchak, and R.W. DeSanctis, Clinical spectrum of the sick sinus syndrome. Circulation, 1972;46: 5–13.

    CrossRef  PubMed  CAS  Google Scholar 

  60. Short, D.S., The syndrome of alternating bradycardia and tachycardia. Br. Heart J., 1954;16: 208–214.

    CrossRef  PubMed  CAS  Google Scholar 

  61. Andersen, H.R., J.C. Nielsen, P.E. Thomsen, L. Thuesen, T. Vesterlund, A.K. Pedersen, et al., Atrioventricular conduction during long-term follow-up of patients with sick sinus syndrome. Circulation, 1998;98: 1315–1321.

    CrossRef  PubMed  CAS  Google Scholar 

  62. Walter, P.F., I.S. Crawley, and E.R. Dorney, Carotid sinus hypersensitivity and syncope. Am. J. Cardiol., 1978;42: 396–403.

    CrossRef  PubMed  CAS  Google Scholar 

  63. Davies, A.B., M.R. Stephens, and A.G. Davies, Carotid sinus hypersensitivity in patients presenting with syncope. Br. Heart J., 1979;42: 583–586.

    CrossRef  PubMed  CAS  Google Scholar 

  64. Sutton, R. and R.A. Kenny, The natural history of sick sinus syndrome. Pace Clin. Electrophysiol., 1986;9: 1110–1114.

    CrossRef  CAS  Google Scholar 

  65. Ferrer, M.I., The etiology and natural history of sinus node disorders. Arch. Intern. Med., 1982;142: 371–372.

    PubMed  CAS  Google Scholar 

  66. Simonsen, E., J.S. Nielsen, and B.L. Nielsen, Sinus node dysfunction in 128 patients. A retrospective study with follow-up. Acta Med. Scand., 1980;208: 343–348.

    CrossRef  PubMed  CAS  Google Scholar 

  67. Denes, P., L. Levy, A. Pick, and K.M. Rosen, The incidence of typical and atypical A-V Wenckebach periodicity. Am. Heart J., 1975;89: 26–31.

    CrossRef  PubMed  CAS  Google Scholar 

  68. Crook, B.R., P.M. Cashman, F.D. Stott, and E.B. Raftery, Tape monitoring of the electrocardiogram in ambulant patients with sinoatrial disease. Br. Heart J., 1973;35: 1009–1013.

    CrossRef  PubMed  CAS  Google Scholar 

  69. Reiffel, J.A., J.T. Bigger Jr., M. Cramer, and D.S. Reid, Ability of Holter electrocardiographic recording and atrial stimulation to detect sinus nodal dysfunction in symptomatic and asymptomatic patients with sinus bradycardia. Am. J. Cardiol., 1977;40: 189–194.

    CrossRef  PubMed  CAS  Google Scholar 

  70. Krahn, A.D., G.J. Klein, R. Yee, and C. Norris, Final results from a pilot study with an implantable loop recorder to determine the etiology of syncope in patients with negative noninvasive and invasive testing. Am. J. Cardiol., 1998;82: 117–119.

    CrossRef  PubMed  CAS  Google Scholar 

  71. Reiffel, J.A., R. Schwarzberg, and M. Murry, Comparison of autotriggered memory loop recorders versus standard loop recorders versus 24-hour Holter monitors for arrhythmia detection. Am. J. Cardiol., 2005;95: 1055–1059.

    CrossRef  PubMed  Google Scholar 

  72. Kantelip, J.P., E. Sage, and P. Duchene-Marullaz, Findings on ambulatory electrocardiographic monitoring in subjects older than 80 years. Am. J. Cardiol., 1986;57: 398–401.

    CrossRef  PubMed  CAS  Google Scholar 

  73. Molgaard, H., K.E. Sorensen, and P. Bjerregaard, Minimal heart rates and longest pauses in healthy adult subjects on two occasions eight years apart. Eur. Heart J., 1989;10: 758–764.

    PubMed  CAS  Google Scholar 

  74. Mazuz, M. and H.S. Friedman, Significance of prolonged electrocardiographic pauses in sinoatrial disease: sick sinus syndrome. Am. J. Cardiol., 1983;52: 485–489.

    CrossRef  PubMed  CAS  Google Scholar 

  75. Abbott, J.A., D.S. Hirschfeld, F.W. Kunkel, M.M. Scheinman, and G. Modin, Graded exercise testing in patients with sinus node dysfunction. Am. J. Med., 1977;62: 330–338.

    CrossRef  PubMed  CAS  Google Scholar 

  76. Dhingra, R.C., F. Amat-y-Leon, C. Wyndham, P. Denes, D. Wu, R.H. Miller, et al., Electrophysiologic effects of atropine on sinus node and atrium in patients with sinus nodal dysfunction. Am. J. Cardiol., 1976;38: 848–855.

    CrossRef  PubMed  CAS  Google Scholar 

  77. Strauss, H.C., J.T. Bigger, A.L. Saroff, and E.G. Giardina, Electrophysiologic evaluation of sinus node function in patients with sinus node dysfunction. Circulation, 1976;53: 763–776.

    CrossRef  PubMed  CAS  Google Scholar 

  78. Cleaveland, C.R., R.E. Rangno, and D.G. Shand, A standardized isoproterenol sensitivity test. The effects of sinus arrhythmia, atropine, and propranolol. Arch. Intern. Med., 1972;130: 47–52.

    CrossRef  PubMed  CAS  Google Scholar 

  79. Jose, A.D. and D. Collison, The normal range and determinants of the intrinsic heart rate in man. Cardiovasc. Res., 1970;4: 160–167.

    CrossRef  PubMed  CAS  Google Scholar 

  80. Jordan, J.L., I. Yamaguchi, and W.J. Mandel, Studies on the mechanism of sinus node dysfunction in the sick sinus syndrome. Circulation, 1978;57: 217–223.

    CrossRef  PubMed  CAS  Google Scholar 

  81. Szatmary, L.J., Autonomic blockade and sick sinus syndrome. New concept in the interpretation of electrophysiological and Holter data. Eur. Heart J., 1984;5: 637–648.

    PubMed  CAS  Google Scholar 

  82. Hariman, R.J., E. Krongrad, R.A. Boxer, M.B. Weiss, C.N. Steeg, and B.F .Hoffman, Method for recording electrical activity of the sinoatrial node and automatic atrial foci during cardiac catheterization in human subjects. Am. J. Cardiol., 1980;45: 775–781.

    CrossRef  PubMed  CAS  Google Scholar 

  83. Gomes, J.A., P.S. Kang, and N. El Sherif, The sinus node electrogram in patients with and without sick sinus syndrome: techniques and correlation between directly measured and indirectly estimated sinoatrial conduction time. Circulation, 1982;66: 864–873.

    CrossRef  PubMed  CAS  Google Scholar 

  84. Reiffel, J.A., E. Gang, J. Gliklich, M.B. Weiss, J.C. Davis, J.N. Patton, et al., The human sinus node electrogram: a transvenous catheter technique and a comparison of directly measured and indirectly estimated sinoatrial conduction time in adults. Circulation, 1980;62: 1324–1334.

    CrossRef  PubMed  CAS  Google Scholar 

  85. Josephson, M.E., Sinus Node Function. Clinical Cardiac Electrophysiology: Techniques and Interpretations, 4th edn. Philadelphia, PA: Lippincott Williams & Wilkins, 2008, pp. 69–92.

    Google Scholar 

  86. Reiffel, J.A., Electrophysiologic evaluation of sinus node function. Cardiol. Clin., 1986;4: 401–416.

    PubMed  CAS  Google Scholar 

  87. Yee, R. and H.C. Strauss, Electrophysiologic mechanisms: sinus node dysfunction. Circulation, 1987;75: III12–III18.

    PubMed  CAS  Google Scholar 

  88. Vassalle, M., The relationship among cardiac pacemakers. Overdrive suppression. Circ. Res., 1977;41: 269–277.

    CrossRef  PubMed  CAS  Google Scholar 

  89. Narula, O.S., P. Samet, and R.P. Javier, Significance of the sinus-node recovery time. Circulation, 1972;45: 140–158.

    CrossRef  PubMed  CAS  Google Scholar 

  90. Mandel, W.J., H. Hayakawa, H.N. Allen, R. Danzig, and A.I. Kermaier, Assessment of sinus node function in patients with the sick sinus syndrome. Circulation, 1972;46: 761–769.

    CrossRef  PubMed  CAS  Google Scholar 

  91. Benditt, D.G., H.C. Strauss, M.M. Scheinman, V.S. Behar, and A.G. Wallace, Analysis of secondary pauses following termination of rapid atrial pacing in man. Circulation, 1976;54: 436–441.

    CrossRef  PubMed  CAS  Google Scholar 

  92. Strauss, H.C., A.L. Saroff, J.T. Bigger Jr., and E.G. Giardina, Premature atrial stimulation as a key to the understanding of sinoatrial conduction in man. Presentation of data and critical review of the literature. Circulation, 1973;47: 86–93.

    CrossRef  PubMed  CAS  Google Scholar 

  93. Narula, O.S., N. Shantha, M. Vasquez, W.D. Towne, and J.W. Linhart, A new method for measurement of sinoatrial conduction time. Circulation, 1978;58: 706–714.

    CrossRef  PubMed  CAS  Google Scholar 

  94. Breithardt, G. and L. Seipel, Comparative study of two methods of estimating sinoatrial conduction time in man. Am. J. Cardiol., 1978;42: 965–972.

    CrossRef  PubMed  CAS  Google Scholar 

  95. Kerr, C.R. and H.C. Strauss, The measurement of sinus node refractoriness in man. Circulation, 1983;68: 1231–1237.

    CrossRef  PubMed  CAS  Google Scholar 

  96. Juillard, A., F. Guillerm, H.V. Chuong, A. Barrillon, and A. Gerbaux, Sinus node electrogram recording in 59 patients. Comparison with simultaneous estimation of sinoatrial conduction using premature atrial stimulation. Br. Heart J., 1983;50: 75–84.

    CrossRef  PubMed  CAS  Google Scholar 

  97. Asseman, P., B. Berzin, D. Desry, D. Vilarem, P. Durand, C. Delmotte, et al., Persistent sinus nodal electrograms during abnormally prolonged postpacing atrial pauses in sick sinus syndrome in humans: sinoatrial block vs. overdrive suppression. Circulation, 1983;68: 33–41.

    CrossRef  PubMed  CAS  Google Scholar 

  98. Asseman, P., B. Berzin, D. Desry, J.J. Bauchart, R. Reade, O. Leroy, et al., Postextrasystolic sinoatrial exit block in human sick sinus syndrome: demonstration by direct recording of sinus node electrograms. Am. Heart J., 1991;122: 1633–1643.

    CrossRef  PubMed  CAS  Google Scholar 

  99. Fujimura, O., R. Yee, G.J. Klein, A.D. Sharma, and K.A. Boahene, The diagnostic sensitivity of electrophysiologic testing in patients with syncope caused by transient bradycardia. N. Engl. J. Med., 1989;321: 1703–1707.

    CrossRef  PubMed  CAS  Google Scholar 

  100. Kang, P.S., J.A. Gomes, and N. El Sherif, Differential effects of functional autonomic blockade on the variables of sinus nodal automaticity in sick sinus syndrome. Am. J. Cardiol., 1982;49: 273–282.

    CrossRef  PubMed  CAS  Google Scholar 

  101. Bergfeldt, L., H. Vallin, M. Rosenqvist, P. Insulander, R. Nordlander, and H. Astrom, Sinus node recovery time assessment revisited: role of pharmacologic blockade of the autonomic nervous system. J. Cardiovasc. Electrophysiol., 1996;7: 95–101.

    CrossRef  PubMed  CAS  Google Scholar 

  102. Gann, D., A. Tolentino, and P. Samet, Electrophysiologic evaluation of elderly patients with sinus bradycardia: a long-term follow-up study. Ann. Intern. Med., 1979;90: 24–29.

    PubMed  CAS  Google Scholar 

  103. Shaw, D.B., R.R. Holman, and J.I. Gowers, Survival in sinoatrial disorder (sick-sinus syndrome). Br. Med. J., 1980;280: 139–141.

    CrossRef  PubMed  CAS  Google Scholar 

  104. Dhingra, R.C., F. Amat-y-Leon, C. Wyndham, P.C. Deedwania, D. Wu, P. Denes, et al., Clinical significance of prolonged sinoatrial conduction time. Circulation, 1977;55: 8–15.

    CrossRef  PubMed  CAS  Google Scholar 

  105. Teichman, S.L., S.D. Felder, J.A. Matos, S.G. Kim, L.E. Waspe, and J.D. Fisher, The value of electrophysiologic studies in syncope of undetermined origin: report of 150 cases. Am. Heart J., 1985;110: 469–479.

    CrossRef  PubMed  CAS  Google Scholar 

  106. Gang, E.S., J.A. Reiffel, F.D. Livelli Jr., and J.T. Bigger Jr., Sinus node recovery times following the spontaneous termination of supraventricular tachycardia and following atrial overdrive pacing: a comparison. Am. Heart J., 1983;105: 210–215.

    CrossRef  PubMed  CAS  Google Scholar 

  107. van Mechelen, R., A. Segers, and F. Hagemeijer, Serial electrophysiologic studies after single chamber atrial pacemaker implantation in patients with symptomatic sinus node dysfunction. Eur. Heart J., 1984;5: 628–636.

    PubMed  CAS  Google Scholar 

  108. Blomstrom-Lundqvist, C., M.M. Scheinman, E.M. Aliot, J.S. Alpert, H. Calkins, A.J. Camm, et al., ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias – executive summary. A report of the American college of cardiology/American heart association task force on practice guidelines and the European society of cardiology committee for practice guidelines (writing committee to develop guidelines for the management of patients with supraventricular arrhythmias) developed in collaboration with NASPE-Heart Rhythm Society. J. Am. Coll. Cardiol., 2003;42: 1493–1531.

    CrossRef  PubMed  Google Scholar 

  109. Chen, S.A., C.T. Tai, C.E. Chiang, and M.S. Chang, Role of the surface electrocardiogram in the diagnosis of patients with supraventricular tachycardia. Cardiol. Clin., 1997;15: 539–565.

    CrossRef  PubMed  CAS  Google Scholar 

  110. Obel, O.A. and A.J. Camm, Supraventricular tachycardia. ECG diagnosis and anatomy. Eur. Heart J., 1997;18(Suppl. C): 2–11.

    CrossRef  Google Scholar 

  111. Hoffman, B.F. and M.R. Rosen, Cellular mechanisms for cardiac arrhythmias. Circ. Res., 1981;49: 1–15.

    CrossRef  PubMed  CAS  Google Scholar 

  112. Zorn-Pauly, K., P. Schaffer, B. Pelzmann, P. Lang, H. Machler, B. Rigler, et al., If in left human atrium: a potential contributor to atrial ectopy. Cardiovasc. Res., 2004;64: 250–259.

    CrossRef  PubMed  CAS  Google Scholar 

  113. Tsai, C.F., C.T. Tai, M.H. Hsieh, W.S. Lin, W.C. Yu, K.C. Ueng, et al., Initiation of atrial fibrillation by ectopic beats originating from the superior vena cava: electrophysiological characteristics and results of radiofrequency ablation. Circulation, 2000;102: 67–74.

    CrossRef  PubMed  CAS  Google Scholar 

  114. Haissaguerre, M., P. Jais, D.C. Shah, A. Takahashi, M. Hocini, G. Quiniou, et al., Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N. Engl. J. Med., 1998;339: 659–666.

    CrossRef  PubMed  CAS  Google Scholar 

  115. Wit, A.L. and M.R. Rosen, Afterdepolarizations and triggered activity: distinction from automaticity as an arrhythmogenic mechanism, in The Heart and Cardiovascular System, H.A. Fozzard, E. Haber, R.B. Jennings, A.M. Katz, and H.E. Morgan, Editors. New York: Raven Press, 1992, pp. 2113–2163.

    Google Scholar 

  116. Lederer, W.J. and R.W. Tsien, Transient inward current underlying arrhythmogenic effects of cardiotonic steroids in Purkinje fibres. J. Physiol. (Lond.), 1976;263: 73–100.

    CAS  Google Scholar 

  117. Fedida, D., D. Noble, A.C. Rankin, and A.J. Spindler, The arrhythmogenic transient inward current iTI and related contraction in isolated guinea-pig ventricular myocytes. J. Physiol. (Lond.), 1987;392: 523–542.

    CAS  Google Scholar 

  118. Rosen, M.R. and R.F. Reder, Does triggered activity have a role in the genesis of cardiac arrhythmias? Ann. Intern. Med., 1981;94: 794–801.

    PubMed  CAS  Google Scholar 

  119. Saoudi, N., F. Cosio, A. Waldo, S.A. Chen, Y. Iesaka, M. Lesh, et al., Classification of atrial flutter and regular atrial tachycardia according to electrophysiologic mechanism and anatomic bases: a statement from a joint expert group from the Working Group of Arrhythmias of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. J. Cardiovasc. Electrophysiol., 2001;12: 852–866.

    CrossRef  PubMed  CAS  Google Scholar 

  120. Wellens, H.J., Value and limitations of programmed electrical stimulation of the heart in the study and treatment of tachycardias. Circulation, 1978;57: 845–853.

    CrossRef  PubMed  CAS  Google Scholar 

  121. MacLean, W.A., R.B. Karp, N.T. Kouchoukos, T.N. James, and A.L. Waldo, P waves during ectopic atrial rhythms in man: a study utilizing atrial pacing with fixed electrodes. Circulation, 1975;52: 426–434.

    CrossRef  PubMed  CAS  Google Scholar 

  122. Tang, C.W., M.M. Scheinman, G.F. Van Hare, L.M. Epstein, A.P. Fitzpatrick, R.J. Lee, et al., Use of P wave configuration during atrial tachycardia to predict site of origin. J. Am. Coll. Cardiol., 1995;26: 1315–1324.

    CrossRef  PubMed  CAS  Google Scholar 

  123. Wu, D., P. Denes, F. Amat-y-Leon, R.C. Chhablani, and K.M. Rosen, Limitation of the surface electrocardiogram in diagnosis of atrial arrhythmias. Further observations on dissimilar atrial rhythms. Am. J. Cardiol., 1975;36: 91–97.

    CrossRef  PubMed  CAS  Google Scholar 

  124. Man, K.C., Chan, K.K., P. Kovack, R. Goyal, F. Bogun, M. Harvey, et al., Spatial resolution of atrial pace mapping as determined by unipolar atrial pacing at adjacent sites. Circulation, 1996;94: 1357–1363.

    CrossRef  PubMed  CAS  Google Scholar 

  125. Josephson, M.E., D.L. Scharf, J.A. Kastor, and J.G. Kitchen, Atrial endocardial activation in man. Electrode catheter technique of endocardial mapping. Am. J. Cardiol., 1977;39: 972–981.

    CrossRef  PubMed  CAS  Google Scholar 

  126. Wells, J.L. Jr., W.A. MacLean, T.N. James, and A.L. Waldo, Characterization of atrial flutter. Studies in man after open heart surgery using fixed atrial electrodes. Circulation, 1979;60: 665–673.

    CrossRef  PubMed  Google Scholar 

  127. Killip, T. and J.H. Gault, Mode of onset of atrial fibrillation in man. Am. Heart J., 1965;70: 172–179.

    CrossRef  PubMed  CAS  Google Scholar 

  128. Bennett, M.A. and B.L. Pentecost, The pattern of onset and spontaneous cessation of atrial fibrillation in man. Circulation, 1970;41: 981–988.

    CrossRef  PubMed  CAS  Google Scholar 

  129. Cosio, F.G., F. Arribas, and M. Lopez-Gil, Electrophysiologic findings in atrial fibrillation, in Atrial Fibrillation: Mechanisms and Management, R.H. Falk and P.J. Podrid, Editors. Philadelphia, PA: Lippincott-Raven, 1997, pp. 397–410.

    Google Scholar 

  130. Scheinman, M.M., D. Basu, and M. Hollenberg, Electrophysiologic studies in patients with persistent atrial tachycardia. Circulation, 1974;50: 266–273.

    CrossRef  PubMed  CAS  Google Scholar 

  131. Shinbane, J.S., M.A. Wood, D.N. Jensen, K.A. Ellenbogen, A.P. Fitzpatrick, and M.M. Scheinman, Tachycardia-induced cardiomyopathy: a review of animal models and clinical studies. J. Am. Coll. Cardiol., 1997;29: 709–715.

    CrossRef  PubMed  CAS  Google Scholar 

  132. Walker, N.L., S.M. Cobbe, and D.H. Birnie, Tachycardiomyopathy: a diagnosis not to be missed. Heart, 2004;90: e7.

    CrossRef  PubMed  CAS  Google Scholar 

  133. Calo, L., L. Sciarra, R. Scioli, F. Lamberti, M.L. Loricchio, C. Pandozi, et al., Recovery of cardiac function after ablation of atrial tachycardia arising from the tricuspid annulus. Ital. Heart J., 2005;6: 652–657.

    PubMed  Google Scholar 

  134. Raungratanaamporn, O., K. Bhuripanyo, R. Krittayaphong, C. Sriratanasathavorn, S. Raungratanaamporn, C. Kangkagate, et al., Reversibility of tachycardiomyopathy after successful radiofrequency catheter ablation: intermediate results. J. Med. Assoc. Thai., 2001;84: 258–264.

    PubMed  CAS  Google Scholar 

  135. Orth-Gomer, K., C. Hogstedt, L. Bodin, and B. Soderholm, Frequency of extrasystoles in healthy male employees. Br. Heart J., 1986;55: 259–264.

    CrossRef  PubMed  CAS  Google Scholar 

  136. Folarin, V.A., P.J. Fitzsimmons, and W.B. Kruyer, Holter monitor findings in asymptomatic male military aviators without structural heart disease. Aviat. Space Environ. Med., 2001;72: 836–838.

    PubMed  CAS  Google Scholar 

  137. Ramsdale, D.R., N. Arumugam, S.S. Singh, J. Pearson, and R.G. Charles, Holter monitoring in patients with mitral stenosis and sinus rhythm. Eur. Heart J., 1987;8: 164–170.

    PubMed  CAS  Google Scholar 

  138. Waldo, A.L., K.J. Vitikainen, G.A. Kaiser, J.R. Malm, and B.F. Hoffman, The P wave and P-R interval. Effects of the site of origin of atrial depolarization. Circulation, 1970;42: 653–671.

    CrossRef  PubMed  CAS  Google Scholar 

  139. Gouaux, J.L. and R. Ashman, Auricular fibrillation with aberration simulating ventricular paroxysmal tachycardia. Am. Heart J., 1947;34: 366–373.

    CrossRef  PubMed  CAS  Google Scholar 

  140. Fisch, C., D.P. Zipes, and P.L. McHenry, Rate dependent aberrancy. Circulation, 1973;48: 714–724.

    CrossRef  PubMed  CAS  Google Scholar 

  141. Chung, K.Y., T.J. Walsh, and E. Massie, Combined atrial and ventricular parasystole. Am. J. Cardiol., 1965;16: 462–464.

    CrossRef  PubMed  CAS  Google Scholar 

  142. Eliakim, M., Atrial parasystole. Effect of carotid sinus stimulation, Valsalva maneuver and exercise. Am. J. Cardiol., 1965;16: 457–461.

    CrossRef  PubMed  CAS  Google Scholar 

  143. Poutiainen, A.M., M.J. Koistinen, K.E. Airaksinen, E.K. Hartikainen, R.V. Kettunen, J.E. Karjalainen, et al., Prevalence and natural course of ectopic atrial tachycardia. Eur. Heart J., 1999;20: 694–700.

    CrossRef  PubMed  CAS  Google Scholar 

  144. Rodriguez, L.M., C. De Chillou, J. Schlapfer, J. Metzger, X. Baiyan, A. van den Dool, et al., Age at onset and gender of patients with different types of supraventricular tachycardias. Am. J. Cardiol., 1992;70: 1213–1215.

    CrossRef  PubMed  CAS  Google Scholar 

  145. Porter, M.J., J.B. Morton, R. Denman, A.C. Lin, S. Tierney, P.A. Santucci, et al., Influence of age and gender on the mechanism of supraventricular tachycardia. Heart Rhythm, 2004;1: 393–396.

    CrossRef  PubMed  Google Scholar 

  146. Chen, S.A., C.E. Chiang, C.J. Yang, C.C. Cheng, T.J. Wu, S.P. Wang, et al., Sustained atrial tachycardia in adult patients. Electrophysiological characteristics, pharmacological response, possible mechanisms, and effects of radiofrequency ablation. Circulation, 1994;90: 1262–1278.

    CrossRef  PubMed  CAS  Google Scholar 

  147. von Bernuth, G., W. Engelhardt, H.H. Kramer, H. Singer, P. Schneider, H. Ulmer, et al., Atrial automatic tachycardia in infancy and childhood. Eur. Heart J., 1992;13: 1410–1415.

    PubMed  CAS  Google Scholar 

  148. Chen, S.A., C.T. Tai, C.E. Chiang, Y.A. Ding, and M.S. Chang, Focal atrial tachycardia: reanalysis of the clinical and electrophysiologic characteristics and prediction of successful radiofrequency ablation. J. Cardiovasc. Electrophysiol., 1998;9: 355–365.

    CrossRef  PubMed  CAS  Google Scholar 

  149. Kalman, J.M., J.E. Olgin, M.R. Karch, M. Hamdan, R.J. Lee, and M.D. Lesh “Cristal tachycardias”: origin of right atrial tachycardias from the crista terminalis identified by intracardiac echocardiography. J. Am. Coll. Cardiol., 1998;31: 451–459.

    CrossRef  PubMed  CAS  Google Scholar 

  150. Natale, A., L. Breeding, G. Tomassoni, K. Rajkovich, M. Richey, S. Beheiry, et al., Ablation of right and left ectopic atrial tachycardias using a three-dimensional nonfluoroscopic mapping system. Am. J. Cardiol., 1998;82: 989–992.

    CrossRef  PubMed  CAS  Google Scholar 

  151. Anguera, I., J. Brugada, M. Roba, L. Mont, L. Aguinaga, P. Geelen, et al., Outcomes after radiofrequency catheter ablation of atrial tachycardia. Am. J. Cardiol., 2001;87: 886–890.

    CrossRef  PubMed  CAS  Google Scholar 

  152. Knight, B.P., M. Ebinger, H. Oral, M.H. Kim, C. Sticherling, F. Pelosi, et al., Diagnostic value of tachycardia features and pacing maneuvers during paroxysmal supraventricular tachycardia. J. Am. Coll. Cardiol., 2000;36: 574–582.

    CrossRef  PubMed  CAS  Google Scholar 

  153. Benditt, D.G., E.L. Pritchett, W.M. Smith, and J.J. Gallagher, Ventriculoatrial intervals: diagnostic use in paroxysmal supraventricular tachycardia. Ann. Intern. Med., 1979;91: 161–166.

    PubMed  CAS  Google Scholar 

  154. Knight, B.P., A. Zivin, J. Souza, M. Flemming, F. Pelosi, R. Goyal, et al., A technique for the rapid diagnosis of atrial tachycardia in the electrophysiology laboratory. J. Am. Coll. Cardiol., 1999;33: 775–781.

    CrossRef  PubMed  CAS  Google Scholar 

  155. Lown, B., N.F. Wyatt, and H.D. Levine, Paroxysmal atrial tachycardia with block. Circulation, 1960;21: 129–143.

    CrossRef  PubMed  CAS  Google Scholar 

  156. Storstein, O. and K. Rasmussen, Digitalis and atrial tachycardia with block. Br. Heart J., 1974;36: 171–176.

    CrossRef  PubMed  CAS  Google Scholar 

  157. Kistler, P.M., K.C. Roberts-Thomson, H.M. Haqqani, S.P. Fynn, S. Singarayar, J.K. Vohra, et al, P-wave morphology in focal atrial tachycardia - development of an algorithm to predict the anatomical site of origin. J. Am. Coll. Cardiol., 2006;48: 1010–1017.

    CrossRef  PubMed  Google Scholar 

  158. Zipes, D.P., W.E. Gaum, B.C. Genetos, R.D. Glassman, J. Noble, and C. Fisch, Atrial tachycardia without P waves masquerading as an A-V junctional tachycardia. Circulation, 1977;55: 253–260.

    CrossRef  PubMed  CAS  Google Scholar 

  159. Boineau, J.P., T.E. Canavan, R.B. Schuessler, M.E. Cain, P.B. Corr, and J.L. Cox, Demonstration of a widely distributed atrial pacemaker complex in the human heart. Circulation, 1988;77: 1221–1237.

    CrossRef  PubMed  CAS  Google Scholar 

  160. Chen, C.C., C.T. Tai, C.E. Chiang, W.C. Yu, S.H. Lee, Y.J. Chen, et al., Atrial tachycardias originating from the atrial septum: electrophysiologic characteristics and radiofrequency ablation. J. Cardiovasc. Electrophysiol., 2000;11: 744–749.

    CrossRef  PubMed  CAS  Google Scholar 

  161. Frey, B., G. Kreiner, M. Gwechenberger, and H.D. Gossinger, Ablation of atrial tachycardia originating from the vicinity of the atrioventricular node: significance of mapping both sides of the interatrial septum. J. Am. Coll. Cardiol., 2001;38: 394–400.

    CrossRef  PubMed  CAS  Google Scholar 

  162. Marrouche, N.F., A. SippensGroenewegen, Y. Yang, S. Dibs, and M.M. Scheinman, Clinical and electrophysiologic characteristics of left septal atrial tachycardia. J. Am. Coll. Cardiol., 2002;40: 1133–1139.

    CrossRef  PubMed  Google Scholar 

  163. Kistler, P.M., S.P. Fynn, H. Haqqani, I.H. Stevenson, J.K. Vohra, J.B. Morton, et al., Focal atrial tachycardia from the ostium of the coronary sinus: electrocardiographic and electrophysiological characterization and radiofrequency ablation. J. Am. Coll. Cardiol., 2005;45: 1488–1493.

    CrossRef  PubMed  Google Scholar 

  164. Tada, H., A. Nogami, S. Naito, M. Suguta, M. Nakatsugawa, Y. Horie, et al., Simple electrocardiographic criteria for identifying the site of origin of focal right atrial tachycardia. Pace Clin. Electrophysiol., 1998;21: 2431–2439.

    CrossRef  CAS  Google Scholar 

  165. Morton, J.B., P. Sanders, A. Das, J.K. Vohra, P.B. Sparks, and J.M. Kalman, Focal atrial tachycardia arising from the tricuspid annulus: electrophysiologic and electrocardiographic characteristics. J. Cardiovasc. Electrophysiol., 2001;12: 653–659.

    CrossRef  PubMed  CAS  Google Scholar 

  166. Roberts-Thomson, K.C., P.M. Kistler, A.D. McGavigan, R.J. Hillock, I.H. Stevenson, S. Spence, et al., Focal atrial tachycardias arising from the right atrial appendage: electrocardiographic and electrophysiological characteristics and radiofrequency ablation. J. Cardiovasc. Electrophysiol., 2007;18(4): 367–372.

    CrossRef  PubMed  Google Scholar 

  167. Kistler, P.M., P. Sanders, S.P. Fynn, I.H. Stevenson, A. Hussin, J.K. Vohra, et al., Electrophysiological and electrocardiographic characteristics of focal atrial tachycardia originating from the pulmonary veins: acute and long-term outcomes of radiofrequency ablation. Circulation, 2003;108: 1968–1975.

    CrossRef  PubMed  Google Scholar 

  168. Hachiya, H., S. Ernst, F. Ouyang, H. Mavrakis, J. Chun, D. Bansch, et al., Topographic distribution of focal left atrial tachycardias defined by electrocardiographic and electrophysiological data. Circ. J., 2005;69: 205–210.

    CrossRef  PubMed  Google Scholar 

  169. Kistler, P.M., P. Sanders, A. Hussin, J.B. Morton, J.K. Vohra, P.B. Sparks, et al., Focal atrial tachycardia arising from the mitral annulus: electrocardiographic and electrophysiologic characterization. J. Am. Coll. Cardiol., 2003;41: 2212–2219.

    CrossRef  PubMed  Google Scholar 

  170. Gonzalez, M.D., L.J. Contreras, M.R. Jongbloed, J. Rivera, T.P. Donahue, A.B. Curtis, et al., Left atrial tachycardia originating from the mitral annulus-aorta junction. Circulation, 2004;110: 3187–3192.

    CrossRef  PubMed  Google Scholar 

  171. Tritto, M., M. Zardini, R. De Ponti, and J.A. Salerno-Uriarte, Iterative atrial tachycardia originating from the coronary sinus musculature. J. Cardiovasc. Electrophysiol., 2001;12: 1187–1189.

    CrossRef  PubMed  CAS  Google Scholar 

  172. Volkmer, M., M. Antz, J. Hebe, and K.H. Kuck, Focal atrial tachycardia originating from the musculature of the coronary sinus. J. Cardiovasc. Electrophysiol., 2002;13: 68–71.

    CrossRef  PubMed  Google Scholar 

  173. Badhwar, N., J.M. Kalman, P.B. Sparks, P.M. Kistler, M. Attari, M. Berger, et al., Atrial tachycardia arising from the coronary sinus musculature: electrophysiological characteristics and long-term outcomes of radiofrequency ablation. J. Am. Coll. Cardiol., 2005;46: 1921–1930.

    CrossRef  PubMed  Google Scholar 

  174. Shine, K.I., J.A. Kastor, and P.M. Yurchak, Multifocal atrial tachycardia. Clinical and electrocardiographic features in 32 patients. N. Engl. J. Med., 1968;279: 344–349.

    CrossRef  PubMed  CAS  Google Scholar 

  175. McCord, J. and S. Borzak, Multifocal atrial tachycardia. Chest, 1998;113: 203–209.

    CrossRef  PubMed  CAS  Google Scholar 

  176. Lipson, M.J. and S. Naimi, Multifocal atrial tachycardia (chaotic atrial tachycardia). Clinical associations and significance. Circulation, 1970;42: 397–407.

    CrossRef  PubMed  CAS  Google Scholar 

  177. Marchlinski, F.E. and J.M. Miller, Atrial arrhythmias exacerbated by theophylline. Response to verapamil and evidence for triggered activity in man. Chest, 1985;88: 931–934.

    CrossRef  PubMed  CAS  Google Scholar 

  178. Strickberger, S.A., C.B. Miller, and J.H. Levine, Multifocal atrial tachycardia from electrolyte imbalance. Am. Heart J., 1988;115: 680–682.

    CrossRef  PubMed  CAS  Google Scholar 

  179. Levine, J.H., J.R. Michael, and T. Guarnieri, Multifocal atrial tachycardia: a toxic effect of theophylline. Lancet, 1985;1: 12–14.

    CrossRef  PubMed  CAS  Google Scholar 

  180. Wang, K., B.L. Goldfarb, F.L. Gobel, and H.G. Richman, Multifocal atrial tachycardia. Arch. Intern. Med., 1977;137: 161–164.

    CrossRef  PubMed  CAS  Google Scholar 

  181. Bisset, G.S. III, S.F. Seigel, W.E. Gaum, and S. Kaplan, Chaotic atrial tachycardia in childhood. Am. Heart J., 1981;101: 268–272.

    CrossRef  PubMed  Google Scholar 

  182. Arsura, E., A.S. Lefkin, D.L. Scher, M. Solar, and S. Tessler, A randomized, double-blind, placebo-controlled study of verapamil and metoprolol in treatment of multifocal atrial tachycardia. Am. J. Med., 1988;85: 519–524.

    CrossRef  PubMed  CAS  Google Scholar 

  183. McCord, J.K., S. Borzak, T. Davis, and M. Gheorghiade, Usefulness of intravenous magnesium for multifocal atrial tachycardia in patients with chronic obstructive pulmonary disease. Am. J. Cardiol., 1998;81: 91–93.

    CrossRef  PubMed  CAS  Google Scholar 

  184. Tucker, K.J., J. Law, and M.J. Rodriques, Treatment of refractory recurrent multifocal atrial tachycardia with atrioventricular junction ablation and permanent pacing. J. Invasive Cardiol., 1995;7: 207–212.

    PubMed  CAS  Google Scholar 

  185. Ueng, K.C., S.H. Lee, D.J. Wu, C.S. Lin, M.S. Chang, and S.A. Chen, Radiofrequency catheter modification of atrioventricular junction in patients with COPD and medically refractory multifocal atrial tachycardia. Chest, 2000;117: 52–59.

    CrossRef  PubMed  CAS  Google Scholar 

  186. Levine, J.H., J.R. Michael, and T. Guarnieri, Treatment of multifocal atrial tachycardia with verapamil. N. Engl. J. Med., 1985;312: 21–25.

    CrossRef  PubMed  CAS  Google Scholar 

  187. Watson, R.M. and M.E. Josephson, Atrial flutter. I. Electrophysiologic substrates and modes of initiation and termination. Am. J. Cardiol., 1980;45: 732–741.

    CrossRef  PubMed  CAS  Google Scholar 

  188. Waldo, A.L., W.A. MacLean, R.B. Karp, N.T. Kouchoukos, and T.N. James, Entrainment and interruption of atrial flutter with atrial pacing: studies in man following open heart surgery. Circulation, 1977;56: 737–745.

    CrossRef  PubMed  CAS  Google Scholar 

  189. Greenberg, M.L., T.A. Kelly, B.B. Lerman, and J.P. DiMarco, Atrial pacing for conversion of atrial flutter. Am. J. Cardiol., 1986;58: 95–99.

    CrossRef  PubMed  CAS  Google Scholar 

  190. Waldo, A.L., Atrial flutter: entrainment characteristics. J. Cardiovasc. Electrophysiol., 1997;8: 337–352.

    CrossRef  PubMed  CAS  Google Scholar 

  191. Scheinman, M.M., Y. Yang, and J. Cheng, Atrial flutter: Part II Nomenclature. Pace Clin. Electrophysiol., 2004;27: 504–506.

    CrossRef  Google Scholar 

  192. Granada, J., W. Uribe, P.H. Chyou, K. Maassen, R. Vierkant, P.N. Smith, et al., Incidence and predictors of atrial flutter in the general population. J. Am. Coll. Cardiol., 2000;36: 2242–2246.

    CrossRef  PubMed  CAS  Google Scholar 

  193. Lee, K.W., Y. Yang, and M.M. Scheinman, Atrial flutter: a review of its history, mechanisms, clinical features, and current therapy. Curr. Probl. Cardiol., 2005;30: 121–167.

    CrossRef  PubMed  Google Scholar 

  194. Vidaillet, H., J.F. Granada, P.H. Chyou, K. Maassen, M. Ortiz, J.N. Pulido, et al., A population-based study of mortality among patients with atrial fibrillation or flutter. Am. J. Med., 2002;113: 365–370.

    CrossRef  PubMed  Google Scholar 

  195. Kalman, J.M., G.F. VanHare, J.E. Olgin, L.A. Saxon, S.I. Stark, and M.D. Lesh, Ablation of “incisional” reentrant atrial tachycardia complicating surgery for congenital heart disease. Use of entrainment to define a critical isthmus of conduction. Circulation, 1996;93: 502–512.

    CrossRef  PubMed  CAS  Google Scholar 

  196. Chugh, A., H. Oral, K. Lemola, B. Hall, P. Cheung, E. Good, et al., Prevalence, mechanisms, and clinical significance of macroreentrant atrial tachycardia during and following left atrial ablation for atrial fibrillation. Heart Rhythm, 2005;2: 464–471.

    CrossRef  PubMed  Google Scholar 

  197. Stevenson, I.H., P.M. Kistler, S.J. Spence, J.K. Vohra, P.B. Sparks, J.B. Morton, et al., Scar-related right atrial macroreentrant tachycardia in patients without prior atrial surgery: electroanatomic characterization and ablation outcome. Heart Rhythm, 2005;2: 594–601.

    CrossRef  PubMed  Google Scholar 

  198. Wellens, H.J., Contemporary management of atrial flutter. Circulation, 2002;106: 649–652.

    CrossRef  PubMed  Google Scholar 

  199. Natale, A., K.H. Newby, E. Pisano, F. Leonelli, R. Fanelli, D. Potenza, et al., Prospective randomized comparison of antiarrhythmic therapy versus first-line radiofrequency ablation in patients with atrial flutter. J. Am. Coll. Cardiol., 2000;35: 1898–1904.

    CrossRef  PubMed  CAS  Google Scholar 

  200. Tai, C.T., T.Y. Liu, P.C. Lee, Y.J. Lin, M.S. Chang, and S.A. Chen, Non-contact mapping to guide radiofrequency ablation of atypical right atrial flutter. J. Am. Coll. Cardiol., 2004;44: 1080–1086.

    CrossRef  PubMed  Google Scholar 

  201. Della, B.P., A. Fraticelli, C. Tondo, S. Riva, G. Fassini, and C. Carbucicchio, Atypical atrial flutter: clinical features, electrophysiological characteristics and response to radiofrequency catheter ablation. Europace, 2002;4: 241–253.

    CrossRef  PubMed  Google Scholar 

  202. Jais, P., M. Hocini, R. Weerasoryia, L. Macle, C. Scavee, F. Raybaud, et al., Atypical left atrial flutters. Card. Electrophysiol. Rev., 2002;6: 371–377.

    CrossRef  PubMed  Google Scholar 

  203. Olshansky, B., Advances in atrial flutter mapping: what goes around comes around. J. Cardiovasc. Electrophysiol., 2004;15: 415–417.

    CrossRef  PubMed  Google Scholar 

  204. Mehta, A.V. and L.L. Ewing, Atrial tachycardia in infants and children: electrocardiographic classification and its significance. Pediatr. Cardiol., 1993;14: 199–203.

    CrossRef  PubMed  CAS  Google Scholar 

  205. Olgin, J.E., J.M. Kalman, A.P. Fitzpatrick, and M.D. Lesh, Role of right atrial endocardial structures as barriers to conduction during human type I atrial flutter. Activation and entrainment mapping guided by intracardiac echocardiography. Circulation, 1995;92: 1839–1848.

    CrossRef  PubMed  CAS  Google Scholar 

  206. Kalman, J.M., J.E. Olgin, L.A. Saxon, W.G. Fisher, R.J. Lee, and M.D. Lesh, Activation and entrainment mapping defines the tricuspid annulus as the anterior barrier in typical atrial flutter. Circulation, 1996;94: 398–406.

    CrossRef  PubMed  CAS  Google Scholar 

  207. Schwartzman, D., D.J. Callans, C.D. Gottlieb, S.M. Dillon, C. Movsowitz, and F.E. Marchlinski, Conduction block in the inferior vena caval-tricuspid valve isthmus: association with outcome of radiofrequency ablation of type I atrial flutter. J. Am. Coll. Cardiol., 1996;28: 1519–1531.

    CrossRef  PubMed  CAS  Google Scholar 

  208. Saoudi, N., M. Nair, A. Abdelazziz, H. Poty, A. Daou, F. Anselme, et al., Electrocardiographic patterns and results of radiofrequency catheter ablation of clockwise type I atrial flutter. J. Cardiovasc. Electrophysiol., 1996;7: 931–942.

    CrossRef  PubMed  CAS  Google Scholar 

  209. Besoain-Santander, M., A. Pick, and R. Langendorf, A-V conduction in auricular flutter. Circulation, 1950;2: 604–616.

    CrossRef  PubMed  CAS  Google Scholar 

  210. Kennelly, B.M. and G.K. Lane, Electrophysiological studies in four patients with atrial flutter with 1:1 atrioventricular conduction. Am. Heart J., 1978;96: 723–730.

    CrossRef  PubMed  CAS  Google Scholar 

  211. Moleiro, F., I.J. Mendoza, V. Medina-Ravell, A. Castellanos, and R.J. Myerburg, One to one atrioventricular conduction during atrial pacing at rates of 300/minute in absence of Wolff-Parkinson-White Syndrome. Am. J. Cardiol., 1981;48: 789–796.

    CrossRef  PubMed  CAS  Google Scholar 

  212. Bochoeyer, A., Y. Yang, J. Cheng, R.J. Lee, E.C. Keung, N.F. Marrouche, et al., Surface electrocardiographic characteristics of right and left atrial flutter. Circulation, 2003;108: 60–66.

    CrossRef  PubMed  Google Scholar 

  213. Selzer, A., Atrial fibrillation revisited. N. Engl. J. Med., 1982;306: 1044–1045.

    CrossRef  PubMed  CAS  Google Scholar 

  214. Lewis, T., Auricular fibrillation: a common clinical condition. Br. Med. J., 1909;2: 1528.

    CrossRef  PubMed  CAS  Google Scholar 

  215. McMichael, J., History of atrial fibrillation 1628–1819 Harvey – de Senac – Laennec. Br. Heart J., 1982;48: 193–197.

    CrossRef  PubMed  CAS  Google Scholar 

  216. Levy, S., G. Breithardt, R.W. Campbell, A.J. Camm, J.C. Daubert, M. Allessie, et al., Atrial fibrillation: current knowledge and recommendations for management. Working Group on Arrhythmias of the European Society of Cardiology. Eur. Heart J., 1998;19: 1294–1320.

    CrossRef  PubMed  CAS  Google Scholar 

  217. Fuster V., L.E. Rydn, D.S. Cannom, H.J. Crijns, A.B. Curtis, K.A. Ellenbogen, et al, ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation). J. Am. Coll. Cardiol., 2006;48:e149–246.

    CrossRef  Google Scholar 

  218. Nattel, S., New ideas about atrial fibrillation 50 years on. Nature, 2002;415: 219–226.

    CrossRef  PubMed  CAS  Google Scholar 

  219. Quinn, F.R. and A.C. Rankin, Atrial fibrillation ablation in the real world. Heart, 2005;91: 1507–1508.

    CrossRef  PubMed  CAS  Google Scholar 

  220. Oral, H., Mechanisms of atrial fibrillation: lessons from studies in patients. Prog. Cardiovasc. Dis., 2005;48: 29–40.

    CrossRef  PubMed  Google Scholar 

  221. Hwang, C., T.J. Wu, R.N. Doshi, C.T. Peter, and P.S. Chen, Vein of marshall cannulation for the analysis of electrical activity in patients with focal atrial fibrillation. Circulation, 2000;101: 1503–1505.

    CrossRef  PubMed  CAS  Google Scholar 

  222. Moe, G.K., On the multiple wavelet hypothesis of atrial fibrillation. Arch. Int. Pharmacodyn. Ther., 1962;140: 183–188.

    Google Scholar 

  223. Moe, G.K., W.C. Rheinboldt, and J.A. Abildskov, A computer model of atrial fibrillation. Am. Heart J., 1964;67: 200–220.

    CrossRef  PubMed  CAS  Google Scholar 

  224. Allessie, M.A., W.J.P. Lammers, and F.I.M. Bonke, Experimental evaluation of Moe’s multiple wavelet hypothesis of atrial fibrillation, in Cardiac Electrophysiology and Arrhythmias, D.P. Zipes and J. Jalife, Editors. Orlando, FL: Grune and Statton, 1985, pp. 265–275.

    Google Scholar 

  225. Cox, J.L., R.B. Schuessler, and J.P. Boineau, The development of the Maze procedure for the treatment of atrial fibrillation. Semin. Thorac. Cardiovasc. Surg., 2000;12: 2–14.

    CrossRef  PubMed  CAS  Google Scholar 

  226. Jalife, J., O. Berenfeld, and M. Mansour, Mother rotors and fibrillatory conduction: a mechanism of atrial fibrillation. Cardiovasc. Res., 2002;54: 204–216.

    CrossRef  PubMed  CAS  Google Scholar 

  227. Ricard, P., S. Levy, J. Trigano, F. Paganelli, E. Daoud, K.C. Man, et al., Prospective assessment of the minimum energy needed for external electrical cardioversion of atrial fibrillation. Am. J. Cardiol., 1997;79: 815–816.

    CrossRef  PubMed  CAS  Google Scholar 

  228. Wijffels, M.C., C.J. Kirchhof, R. Dorland, and M.A. Allessie, Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats. Circulation, 1995;92: 1954–1968.

    CrossRef  PubMed  CAS  Google Scholar 

  229. Nattel, S., A. Shiroshita-Takeshita, B.J. Brundel, and L. Rivard, Mechanisms of atrial fibrillation: lessons from animal models. Prog. Cardiovasc. Dis., 2005;48: 9–28.

    CrossRef  PubMed  CAS  Google Scholar 

  230. Euler, D.E., B. Olshansky, and S.Y. Kim, Reflex vagal control of atrial repolarization. Am. J. Physiol., 1996;271: H870–H875.

    PubMed  CAS  Google Scholar 

  231. Alessi, R., M. Nusynowitz, J.A. Abildskov, and G.K. Moe, Nonuniform distribution of vagal effects on the atrial refractory period. Am. J. Physiol., 1958;194: 406–410.

    PubMed  CAS  Google Scholar 

  232. Euler, D.E. and P.J. Scanlon, Acetylcholine release by a stimulus train lowers atrial fibrillation threshold. Am. J. Physiol., 1987;253: H863–H868.

    PubMed  CAS  Google Scholar 

  233. Olshansky, B., Interrelationships between the autonomic nervous system and atrial fibrillation. Prog. Cardiovasc. Dis., 2005;48: 57–78.

    CrossRef  PubMed  CAS  Google Scholar 

  234. Coumel, P., Clinical approach to paroxysmal atrial fibrillation. Clin. Cardiol., 1990;13: 209–212.

    CrossRef  PubMed  CAS  Google Scholar 

  235. Oral, H., A. Chugh, C. Scharf, B. Hall, P. Cheung, S. Veerareddy, et al., Pulmonary vein isolation for vagotonic, adrenergic, and random episodes of paroxysmal atrial fibrillation. J. Cardiovasc. Electrophysiol., 2004;15: 402–406.

    CrossRef  PubMed  Google Scholar 

  236. Pappone, C., V. Santinelli, F. Manguso, G. Vicedomini, F. Gugliotta, G. Augello, et al., Pulmonary vein denervation enhances long-term benefit after circumferential ablation for paroxysmal atrial fibrillation. Circulation, 2004;109: 327–334.

    CrossRef  PubMed  Google Scholar 

  237. Wolf, P.A., R.D. Abbott, and W.B. Kannel, Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke, 1991;22: 983–988.

    CrossRef  PubMed  CAS  Google Scholar 

  238. Lloyd-Jones, D.M., T.J. Wang, E.P. Leip, M.G. Larson, D. Levy, R.S. Vasan, et al., Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation, 2004;110: 1042–1046.

    CrossRef  PubMed  Google Scholar 

  239. Benjamin, E.J., D. Levy, S.M. Vaziri, R.B. D’Agostino, A.J. Belanger, and P.A. Wolf, Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study. JAMA, 1994;271: 840–844.

    CrossRef  PubMed  CAS  Google Scholar 

  240. Tsang, T.S., Y. Miyasaka, M.E. Barnes, and B.J. Gersh, Epidemiological profile of atrial fibrillation: a contemporary perspective. Prog. Cardiovasc. Dis., 2005;48: 1–8.

    CrossRef  PubMed  Google Scholar 

  241. Forfar, J.C., H.C. Miller, and A.D. Toft, Occult thyrotoxicosis: a correctable cause of “idiopathic” atrial fibrillation. Am. J. Cardiol., 1979;44: 9–12.

    CrossRef  PubMed  CAS  Google Scholar 

  242. Rathore, S.S., A.K. Berger, K.P. Weinfurt, K.A. Schulman, W.J. Oetgen, B.J. Gersh, et al., Acute myocardial infarction complicated by atrial fibrillation in the elderly: prevalence and outcomes. Circulation, 2000;101: 969–974.

    CrossRef  PubMed  CAS  Google Scholar 

  243. Djousse, L., D. Levy, E.J. Benjamin, S.J. Blease, A. Russ, M.G. Larson, et al., Long-term alcohol consumption and the risk of atrial fibrillation in the Framingham Study. Am. J. Cardiol., 2004;93: 710–713.

    CrossRef  PubMed  CAS  Google Scholar 

  244. Koskinen, P., M. Kupari, H. Leinonen, and K. Luomanmaki, Alcohol and new onset atrial fibrillation: a case-control study of a current series. Br. Heart J., 1987;57: 468–473.

    CrossRef  PubMed  CAS  Google Scholar 

  245. Thornton, J.R., Atrial fibrillation in healthy non-alcoholic people after an alcoholic binge. Lancet, 1984;2: 1013–1015.

    CrossRef  PubMed  CAS  Google Scholar 

  246. Brand, F.N., R.D. Abbott, W.B. Kannel, and P.A. Wolf, Characteristics and prognosis of lone atrial fibrillation. 30-year follow-up in the Framingham Study. JAMA, 1985;254: 3449–3453.

    CrossRef  PubMed  CAS  Google Scholar 

  247. Kopecky, S.L., B.J. Gersh, M.D. McGoon, J.P. Whisnant, D.R. Holmes Jr., D.M. Ilstrup, et al., The natural history of lone atrial fibrillation. A population-based study over three decades. N. Engl. J. Med., 1987;317: 669–674.

    CrossRef  PubMed  CAS  Google Scholar 

  248. Henry, W.L., J. Morganroth, A.S. Pearlman, C.E. Clark, D.R. Redwood, S.B. Itscoitz, et al., Relation between echocardiographically determined left atrial size and atrial fibrillation. Circulation, 1976;53: 273–279.

    CrossRef  PubMed  CAS  Google Scholar 

  249. Aronow, W.S., K.S. Schwartz, and M. Koenigsberg, Prevalence of enlarged left atrial dimension by echocardiography and its correlation with atrial fibrillation and an abnormal P terminal force in lead V1 of the electrocardiogram in 588 elderly persons. Am. J. Cardiol., 1987;59: 1003–1004.

    CrossRef  PubMed  CAS  Google Scholar 

  250. Vaziri, S.M., M.G. Larson, E.J. Benjamin, and D. Levy, Echocardiographic predictors of nonrheumatic atrial fibrillation. The Framingham Heart Study. Circulation, 1994;89: 724–730.

    CrossRef  PubMed  CAS  Google Scholar 

  251. Wang, T.J., M.G. Larson, D. Levy, R.S. Vasan, E.P. Leip, P.A. Wolf, et al., Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study. Circulation, 2003;107: 2920–2925.

    CrossRef  PubMed  Google Scholar 

  252. Morganroth, J., L.N. Horowitz, M.E. Josephson, and J.A. Kastor, Relationship of atrial fibrillatory wave amplitude to left atrial size and etiology of heart disease. An old generalization re-examined. Am. Heart J., 1979;97: 184–186.

    CrossRef  PubMed  CAS  Google Scholar 

  253. Cohen, S.I., S.H. Lau, W.D. Berkowitz, and A.N. Damato, Concealed conduction during atrial fibrillation. Am. J. Cardiol., 1970;25: 416–419.

    CrossRef  PubMed  CAS  Google Scholar 

  254. Wellens, H.J., F.W. Bar, and K.I. Lie, The value of the electrocardiogram in the differential diagnosis of a tachycardia with a widened QRS complex. Am. J. Med., 1978;64: 27–33.

    CrossRef  PubMed  CAS  Google Scholar 

  255. Pritchett, E.L., W.M. Smith, G.J. Klein, S.C. Hammill, and J.J. Gallagher, The “compensatory pause” of atrial fibrillation. Circulation, 1980;62: 1021–1025.

    CrossRef  PubMed  CAS  Google Scholar 

  256. Klein, G.J., T.M. Bashore, T.D. Sellers, E.L. Pritchett, W.M. Smith, and J.J. Gallagher, Ventricular fibrillation in the Wolff-Parkinson-White syndrome. N. Engl. J. Med., 1979;301: 1080–1085.

    CrossRef  PubMed  CAS  Google Scholar 

  257. Campbell, R.W., R.A. Smith, J.J. Gallagher, E.L. Pritchett, and A.G. Wallace, Atrial fibrillation in the preexcitation syndrome. Am. J. Cardiol., 1977;40: 514–520.

    CrossRef  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Glasgow Royal Infirmary, Glasgow, UK

    F. Russell Quinn

  2. Royal Melbourne Hospital, Melbourne, VIC, Australia

    Andrew D. McGavigan

  3. University of Glasgow, Glasgow, UK

    Andrew C. Rankin

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  1. F. Russell Quinn

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  2. Andrew D. McGavigan

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  1. University of Glasgow, Glasgow, UK

    Peter W. Macfarlane

  2. Radboud University Nijmegen, Nijmegen, The Netherlands

    A. van Oosterom

  3. Lund University, Lund, Sweden

    Olle Pahlm

  4. Weill Cornell Medical College, New York, NY, USA

    Paul Kligfield

  5. University of Amsterdam, Amsterdam, The Netherlands

    Michiel Janse

  6. St. George's, University of London, London, UK

    John Camm

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Quinn, F.R., McGavigan, A.D., Rankin, A.C. (2010). 26 Sinus and Atrial Arrhythmias. In: Macfarlane, P.W., van Oosterom, A., Pahlm, O., Kligfield, P., Janse, M., Camm, J. (eds) Comprehensive Electrocardiology. Springer, London. https://doi.org/10.1007/978-1-84882-046-3_26

How does sinus arrhythmia differ from wandering atrial pacemaker?

WAP is differentiated from sinus arrhythmia by the fact that heart rate variability occurs from beat-to-beat, and is not phasic. Also, in sinus arrhythmia, the P-wave morphology and the P-R interval are constant [7]. Most of the arrhythmias occur soon after electric shock and are short-lived.

What is the distinguishing characteristic of the wandering atrial pacemaker rhythm quizlet?

What is the distinguishing characteristic of the wandering atrial pacemaker rhythm? Wandering atrial pacemaker is a: normal finding in children, older adults, and well-conditioned athletes and does not usually cause clinical signs and symptoms.

What are the characteristics of sinus arrhythmia quizlet?

Sinus arrhythmia that is associated with the phases of breathing and changes in intrathoracic pressure is called respiratory sinus arrhythmia. The rhythm is irregular; the heart rate increases gradually during inspiration (R-R intervals shorten) and decreases with expiration (R-R intervals lengthen).

What is the difference between sinus arrhythmia and sinus tachycardia?

The rate in NSR is generally regular but will vary depending on autonomic inputs into the sinus node. When there is irregularity in the sinus rate, it is termed "sinus arrhythmia." A sinus rhythm faster than the normal range is called a sinus tachycardia, while a slower rate is called a sinus bradycardia.